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Chemogenetics

rAAV-hSyn-hM4D(Gi)-P2A-mCherry

hM4Di is an engineered receptor (DREADD) derived from the human muscarinic acetylcholine receptor M4 (hM4D) that responds only to CNO and is no longer activated by acetylcholine. In certain neurons, CNO binding to hM4D activates Gi protein-coupled inward potassium channels (GIRK), leading to cell membrane hyperpolarization and inhibition of neuronal action potential firing.

Product No.CS-2810
Serotype

AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV8, AAV9, retro, AAV11, AAV13, PHP.eB, BR1, B10, MG1.AAV2, olig001, DJ, php.s, 9/retro

Receptor

hM4Di(Gi)

Promoter

Neuron-specific Promoter

Storage

Store at -80°C

Volume
1E+12GC
1E+12GC>1E+14GC
Titer
≥1E+13GC/mL
≥1E+13GC/mL≥5E+12GC/mL
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Delivery Information

Usually Ships in 7 Business Days;

Product Details

Fluorescent Tag

mCherry

Fluorescent Protein Details

mCherry: red fluorescent protein, excitation wavelength 587nm, emission wavelength 610nm.