Chemogenetics
AAV2/9-hSyn-DIO-KORD-IRES-mCitrine-WPRE-pA
AAV2/9
KORD
hSYN(0.5k)
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Delivery Information
Usually Ships in 7 Business Days；
Product Details
Promoter Details
hSyn, human synapsin promoter, mature neuron-specific promoter, 448bp.
Functional Gene Details
KORD: kappa-opioid receptor based DREAAD, which is an artificial receptor modified from the human kappa opioid receptor and is sensitive to SALB (serum albumin) and is not activated by ligands such as opioids. SALB has good blood-brain barrier permeability and has no obvious effect on animals at physiological doses. After SALB binds to KORD, it activates Gi-coupled effector proteins, increases the inward potassium ion current, causes cell membrane hyperpolarization, and inhibits action potential generation. In different cells, the functions of KORD will vary.
Fluorescent Tag
yellow fluorescent yellow
Virus Type
Adeno-associated virus vector Adeno-associated Virus
Expression and Regulation Mode
specific expression
