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Chemogenetics
AAV2/9-hSyn-DIO-hM4D(Gi)-mCerulean-ER2-WPRE-pA
Product No.CS-0693
Serotype
AAV2/9
Receptor
hM4D(Gi)
Promoter
hSYN(0.5k)
Storage
Store at -80°C
Volume
Titer
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Delivery Information
Usually Ships in 7 Business Days；
Product Details
Promoter Details
hSyn, human synapsin promoter, mature neuron-specific promoter, 448bp.
Functional Gene Details
hM4D(Gi): It is an artificial receptor modified from the human muscarinic acetylcholine receptor M4 that only responds to CNO and is no longer activated by acetylcholine. In some neurons, CNO binds to hM4D(Gi) and activates the Gi protein-coupled inward potassium channel GIRK, hyperpolarizing the cell membrane and inhibiting the firing of action potentials in neuronal cells. In cells that do not express GIRK or Gi, hM4D(Gi) functions differently.
Fluorescent Tag
Cyan fluorescent Cyan
Virus Type
Adeno-associated virus vector Adeno-associated Virus
Expression and Regulation Mode
specific expression
