RNAi

rAAV-TBG-mCherry-5'miR-30a-shRNA(Scramble)-3'miR-30a

ShRNA (short hairpin RNA) is a type of RNA molecule used in gene silencing techniques. It is designed to induce the RNA interference (RNAi) pathway, which leads to the degradation of specific mRNA molecules, thereby reducing or "knocking down" the expression of the target gene. The TBG promoter is derived from the human thyroxine-binding globulin gene, which plays a role in thyroid hormone transport. Its specificity and relatively strong activity in the liver make it a valuable tool for studies and therapeutic applications aimed at treating liver-related conditions.