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Optogenetics

rAAV-mDlx-DIO-hChR2(C128S D156A)-EYFP

Remarkable stability of the excited state, with barely detectable return to the dark state even after 30 mins; reduced photocurrent that can be used to induce long-lasting depolarizations.

Product No.CS-2982
Serotype

AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV8, AAV9, retro, AAV11, AAV13, PHP.eB, BR1, B10, MG1.AAV2, olig001, DJ, php.s, 9/retro

Receptor

hChR2(C128S/ D156A)

Promoter

GABAergic interneuron promoter

Storage

Store at -80°C

Volume
1E+12GC
1E+12GC>1E+14GC
Titer
≥1E+13GC/mL
≥1E+13GC/mL≥5E+12GC/mL
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Delivery Information

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Product Details

Functional Gene Details

hChR2(C128S/D156A): Excitation light wavelength is 473nm, single photoactivation has long effect.

Fluorescent Tag

EYFP

Fluorescent Protein Details

EYFP: Yellow fluorescent protein, excitation wavelength 513nm, emission wavelength 527nm.

Expression and Regulation Mode

Cre-dependent

References and DOI

CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice