Excitatory Optogenetics
rAAV-hSyn-DIO-somBiPOLES-mCerulean3
BiPOLES is an optogenetic tool for potent neuronal excitation and inhibition with light of two different wavelengths. Red light is used for activation. Blue light is used for inhibition.
AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV8, AAV9, retro, AAV11, AAV13, PHP.eB, BR1, B10, MG1.AAV2, olig001, DJ, php.s, 9/retro
somBiPOLES
Neuron-specific Promoter
Store at -80°C
Delivery Information
Usually Ships in 7 Business Days；
Product Details
Fluorescent Tag
mCerulean3
Notes
Note that to enhance the effect of bipolarity, somBiPOLE is designed to be more focused on the cell body and dendrites, resulting in weaker signals from fibers. Additionally, this component is a fusion of light-activated and light-inhibitory functional elements, which creates a larger protein structure that may lead to weaker signals. However, according to feedback from actual users, this does not affect the normal functionality.
Expression and Regulation Mode
Cre-dependent
References and DOI
CB1R dysfunction of inhibitory synapses in the ACC drives chronic social isolation stress-induced social impairments in male mice
