Chemogenetics
rAAV-hSyn-DIO-PSAM4-5HT3 HC-P2A-mCherry
A modified variant of the 5-hydroxytryptamine type 3 receptor (5-HT3R) that incorporates the pharmacological properties of Proline-Specific Adenosine Methyltransferase (PSAM) for chemogenetic control. It is composed of 5-HT3R subunits with PSAM4-specific mutations introduced, enabling specific binding to PSAM ligands and generating ion channel activity. PSAM4-5HT3 retains the cation-selective conductance properties of the native 5-HT3 receptor and depolarizes the cell membrane upon activation by the agonist varenicline, thereby allowing neuronal activation. Reference: PMID 3087
AAV1, AAV2, AAV3, AAV4, AAV5, AAV6, AAV8, AAV9, retro, AAV11, AAV13, PHP.eB, BR1, B10, MG1.AAV2, olig001, DJ, php.s, 9/retro
PSAM4-5HT3
hSyn
Store at -80°C
Delivery Information
Usually Ships in 7 Business Days；
Product Details
Promoter Details
hSyn, human synapsin promoter, mature neuron-specific promoter, 448bp.
hS
Fluorescent Tag
mCherry
Fluorescent Protein Details
mCherry: red fluorescent protein, excitation wavelength 587nm, emission wavelength 610nm.
Application
Chemogenetics
Expression and Regulation Mode
Cre-dependent
