Disease Models

rAAV-CMV-α-synuclein(A30P A53T)-P2A-mCherry

The A30P and A53T mutations were first identified in patients with familial Parkinson’s disease and represent point mutations in the SNCA gene. These mutations promote misfolding and aggregation of α-synuclein, facilitating fibril formation and thereby inducing neurotoxicity. In research, the A30P and A53T mutant forms of α-synuclein are frequently used as molecular models of familial Parkinson’s disease.