Chemogenetics
AAV2/PHP.eB-mDlx-hM4D(Gi)-mCherry-WPRE-pA
AAV2/PHP.eB
hM4D(Gi)
mDlx
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Delivery Information
Usually Ships in 7 Business Days；
Product Details
Promoter Details
mDLX, mouse GABAergic interneuron promoter, 530bp.
Functional Gene Details
hM4D(Gi): It is an artificial receptor modified from the human muscarinic acetylcholine receptor M4 that only responds to CNO and is no longer activated by acetylcholine. In some neurons, CNO binds to hM4D(Gi) and activates the Gi protein-coupled inward potassium channel GIRK, hyperpolarizing the cell membrane and inhibiting the firing of action potentials in neuronal cells. In cells that do not express GIRK or Gi, hM4D(Gi) functions differently.
Fluorescent Tag
red fluorescent red
Fluorescent Protein Details
dsRed, red fluorescent protein, excitation wavelength 557nm, emission wavelength 579nm.
Virus Type
Adeno-associated virus vector Adeno-associated Virus
Expression and Regulation Mode
specific expression
