Optogenetics
AAV2/9-mCamKIIa-ChrimsonR-EGFP-WPRE-pA
AAV2/2Retro, AAV2/9
ChrimsonR
mCaMKIIa mCaMKIIa(1.3k)
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Delivery Information
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Product Details
Promoter Details
CaMKIIa, pyramidal neuron/excitatory neuron promoter, 1293bp.
m C aMKIIa promoter, cloned from the promoter region of mouse calmodulin-dependent protein kinase IIa, is 1.3kb in length and is specifically expressed in excitatory neuronal cells.
Functional Gene Details
ChrimsonR: A new type of light-controlled ion channel that can respond to red light around 600nm was discovered through high-throughput sequencing in the Boyden laboratory. A point mutation of K176R was made on the basis of Chrimson (CnChR1), which speeds up the channel closing speed, making it possible to effectively respond to light signals at least 20Hz and below. When used with Chronos, it is possible to control two different neurons with two fluorophores. The excitation light wavelength is 590nm.
Fluorescent Tag
green fluorescent green
Virus Type
Adeno-associated virus vector Adeno-associated Virus
Expression and Regulation Mode
specific expression
